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      Separated by coma
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    CIFRE IFM3R - Institut Régional de Formation aux Métiers de Rééducation et de Réadaptation

    Study of the rhythm mu alpha and of the rhythm mu beta by high-density electroencephalogram ( EEG-HD) at the child with cerebral palsy and unilateral infringement spastique.
    Phd Student : M. Josselin DEMAS
    Director of thesis : Mickael DINOMAIS
    Co-director of thesis : Patrick VAN BOGAERT
    Industriel manager: J.-M. LOUCHET (IFM3R - SAINT-SÉBASTIEN-SUR-LOIRE)

    Beginning of thesis : September 1, 2018

    Team : Information, Signal, Image Processing and Life Sciences

    Contacts : mickael.dinomais @ univ-angers.fr and Patrick.VanBogaert @ chu-angers.fr



    Objective: Spastic unilateral cerebral palsy (PC) is characterized by unilateral involvement of the sensory-motor system. Early motor intervention is recommended to limit the neurological handicap. However, the level of evidence of early rehabilitations is low. The difficulty in evaluating rehabilitations in young children is that the clinical picture changes with age due to cerebral maturation. Therefore, the search for neurophysiological biomarkers for response to rehabilitation is an essential complement to clinical evaluation. The brain rhythms recorded in electroencephalography (EEG) are particularly interesting from this point of view. High-density EEG (EEG-HD), using up to 256 electrodes, is a non-invasive technique that can be performed in infants. Thus, two types of rhythms characterize the sensorimotor system: the mu-beta rhythm, which is poorly described in children, and the mu-alpha rhythm, which according to some authors is a biomarker of performance and perception of action usable at the child from 9 months. The amplitude and frequency of these rhythms will change during childhood and increase with age. EEG-HD studies in adults have shown that these 2 rhythms are generated in different regions of the sensory-motor system. The conditions for recording the EEG-HD signal and signal processing in order to locate the cerebral sources of the rhythms are yet to be developed in the toddler. The main research question is therefore: what are the characteristics of mu alpha rhythm and mu beta rhythm in children aged 12 to 24 months with cerebral palsy with unilateral spastic involvement?

    Method: x children 12 to 24 months of age, with cerebral palsy with unilateral spastic involvement, will be recorded in EEG-HD at rest. The mu alpha and mu beta rhythms will be characterized in terms of power and location. Rhythm modulations, desynchronization and resynchronization, will also be characterized during a motor execution task and an action observation. Electrophysiological data will be correlated with functional evaluation of the upper limbs.

    Conclusion: This research project should allow to establish a methodology fit for analyzing mu rhythms in young children, which would open the way for studies to evaluate the efficacy of different rehabilitation techniques in unilateral spastic PC.