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    MRI and stroke of the child

    MRI and stroke of the child

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      Separated by coma
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    Research project

    MRI and stroke data analysis of the child and physical growth model


    Team: Information, Signal, Image Processing and Life Sciences

    Labeling: none

    Term: 1 year (2018-2019)



    LARIS staff involved: Mickael Dinomais (Chef de clinique en Médecine Physique et de Réadaptation (CHU-Angers)), Mariam Al Harrach (post-doctorante)


    Project Partners: François Rousseau (Professor, expertise in perinatal image processing methods, Brest), Julien Lefèvre (Associate professor, expertise in neonatal brain morphometry, Marseille)



    With a prevalence of 1/2,000 to 1/4,000 live births, perinatal ischemic stroke is the most frequent form of childhood stroke and constitutes the leading cause of unilateral cerebral palsy in term-born children. Perinatal ischemic stroke is an umbrella term including several conditions that differ in pathophysiology, timing and thus in outcomes. Neonatal arterial ischemic stroke (NAIS) refers to a perinatal ischemic stroke syndrome with neonatal signs (mainly iterative focal seizures in the first days of life) related to an arterial infarct as revealed by brain imaging.

    Every case of NAIS is unique to the individual. Considering for instance NAIS leading to unilateral cerebral palsy, one child may have total motor deficit and require early intensive motor rehabilitation therapy, while another with no or mild motor impairment require no or less motor rehabilitation approach. This decision of proposing or not such motor therapy impact the family life, and the decision must be taken in awareness of necessity of such therapy. The variability of the motor prognosis after early brain lesion as represented by NAIS is due in part by the localisation, type of injury and the timing of the injury to the developing brain. The prediction of long-term motor outcome requires new personalized approaches, i.e. patient-specific techniques to understand the causes of the observed disabilities.